Notable artists employing the Wrecking Crew's talents included Nancy Sinatra, Bobby Vee, The Partridge Family, The Mamas & the Papas, The Carpenters, The 5th Dimension, John Denver, The Beach Boys, Simon & Garfunkel, and Nat King Cole.
The figures most often associated with the Wrecking Crew are producer Phil Spector (who used the Crew to create his trademark "Wall of Sound"), and Beach Boys leader Brian Wilson, who used the Crew's talents on many of his mid-1960s productions including the songs "Good Vibrations", "California Girls", the acclaimed album Pet Sounds, and the original recordings for Smile.
Members of the Wrecking Crew played on the first Byrds single recording, "Mr. Tambourine Man", because Columbia Records did not trust the skills of Byrd musicians except for Roger McGuinn. Further recordings of the Byrds were conditional on the success of the single. All of the Byrds played on their subsequent recordings.
Spector used the Wrecking Crew on Leonard Cohen's fifth album, Death of a Ladies' Man.