There aren't really any Mick Jaggers or Ozzy Osbournes in rock for women. Yanno, those iconic rockers that have been in the spot life for practically their entire lives. That makes this a difficult question without any clear cut answers.
When I think of female rocker though the architype that comes to mind for me is none other than Joan Jett. She isn't the biggest but I think she is the biggest that rocks as hard as she does.
And as I re-read this thread I like that my answer hasn't changed in the 3 years since this thread was started.